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KMID : 0895820040140010001
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Journal of Oriental Rehabilitation Medicine
2004 Volume.14 No. 1 p.1 ~ p.18
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The E ffec ts o f Kanghw alSokdan -tan g (Qianghuoxudua n -tang) in Adjuvant-Induced A rthritic A nim a ls
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Kim Geun-Chan
Lee Myeong-Jong
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Abstract
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Objectives: This study was carried out to examine the effect of KanghwalSokdan-tang(Qianghuoxuduan-tang) on anti-inflammatory, analgesic and anti-febrile activities at adjuvant-induced arthritic rats.
Methods: KanghwalSokdan-tang(Qianghuoxuduan-tang) was administered to rats with Adjuvant-induced arthritis and then the rate of increase of paw edema, WBC, RBC, Hemoglobin, ESR, CRP, Protein, albumin, Globulin, GOT, GPT and SOD were measured. KanghwalSokdan-tang(Qianghuoxuduan-tang) was administered to rats with sample group and then writhing syndrome, threshold, recto-temperature and partial-temperature were measured.
Results: 1. It was recognized that KanghwalSokdan-tang(Qianghuoxuduan-tang) constrains increment of Paw Edema effectively.
2. It was recognized that KanghwalSokdan-tang(Qianghuoxuduan-tang) decreases WBC, ESR, SOD and CRP, Globulin were recognized more effectively.
3. It was recognized that KanghwalSokdan-tang(Qianghuoxuduan-tang) increases albumin and Hemoglobin was recognized more effectively.
4. It was recognized that KanghwalSokdan-tang(Qianghuoxuduan-tang) has an anti-febrile effect about the febrile of a joint effectively.
5. It was recognized that KanghwalSokdan-tang(Qianghuoxuduan-tang) has an analgesic effect about the pain and the ncreasing Pressure pain threshold of the paws was recognized more effectively.
Conclusions: According to the above results, it can be concluded KanghwalSokdan-tang(Qianghuoxuduan-tang) showed the treatment effects at adjuvant-induced arthritic rats and on the analgesic effect about the pain at acetic acid- induced mice. It is suggested that it should be studied and developed more throughly for the clinical use.
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KEYWORD
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KanghwalSokdan-tang(Qianghuoxuduan-tang), Freund’s Complete Adjuvant, Arthritis, Analgesic function, Anti-febrile fucntion
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